General information
Organisation
The French Alternative Energies and Atomic Energy Commission (CEA) is a key player in research, development and innovation in four main areas :
• defence and security,
• nuclear energy (fission and fusion),
• technological research for industry,
• fundamental research in the physical sciences and life sciences.
Drawing on its widely acknowledged expertise, and thanks to its 16000 technicians, engineers, researchers and staff, the CEA actively participates in collaborative projects with a large number of academic and industrial partners.
The CEA is established in ten centers spread throughout France
Reference
2025-35201
Division description
The Atomic Energies and Alternative Energies Commission (CEA) is a public research organism, a major actor of research, development and innovation.
Description de l'unité
On the Grenoble CEA campus, the Interdisciplinary Research Institute of Grenoble (IRIG) created in 2019 and affiliated to the CEA's Fundamental Research Direction (DRF) develops research projects in biology and health, nanosciences, cryotechnologies and new technologies for energy and environment.
Physicists, chemists, biologists, physicians, computer scientists and mathematicians contribute together to the fundamental aspects of research projects and to their applications, providing a remarkable ability to answer to societal challenges.
IRIG gathers around 1200 individuals working in nine joint research units (UMR), and in the management team and all support offices and services
The Laboratory of Chemistry and Biology of Metals (LCBM, UMR5249 CEA-CNRS-UGA) is composed of nine teams working at the interface of chemistry and biology. The ProMIT team develops three interconnected research topics
The Laboratory of Chemistry and Biology of Metals includes nine teams working at the chemistry/biology interface. The research themes developped in the ProMIT team are :
• Myeloid cells response to nanoparticles and metal ions,
• B. subtilis response to nanoparticles and metal ions,
• Response of primary human cells to ionizing radiations.
The post-doctoral position is open in the radiobiology group.
Position description
Category
Biology, biophysics and biochemistry
Contract
Fixed-term contract
Job title
Researcher cellular and molecular biology H/F
Socio-professional category
Executive
Contract duration (months)
24
Job description
Exposure to ionizing radiation increases cancer risk. This increase depends at the same time of radiation-related factors and individual factors such as sex, age, genetics and lifestyle. The risk of radiation-induced breast and endometrial cancer is maximum at puberty, probably because of the influence of oestrogens on the development of these tissues. However, irrespective of age at exposure, this risk is higher for women who had early menstruations. Obesity is one of the factors responsible for an early menarche age. It is therefore possible that interactions between leptin and sex hormones increase the radiation-induced cancer risk.
The MIRAMARE project, funded by the Pianoforte European partnership, aims to test this hypothesis in vitro.
Breast and endometrial cells will be exposed to different doses/dose rates of ionizing radiation in the presence and/or absence of leptin and sex hormones, alone and in combinations, to identify changes induced at the genetic, epigenetic, transcriptional and functional levels, with a focus on induction of senescence and modifications of the immune environment.
The partners involved in the MIRAMARE are Stockholm University (SU, Sweden), the University of Campania (UCampania, Naples, Italy), the Silesian University of Technology (SUT, Gliwice, Poland) and the LCBM at CEA-Grenoble, with the collaboration of the UK Health Security Agency (UKHSA, Didcot, UK).
The ProMIT team will mainly address the modulation of the expression of inflammatory factors in irradiated cells, and how these factors are able to modulate the cellular micro-environment.
Applicant Profile
PhD in biology, with a solid background in radiobiology and/or the study of inflammation. You have a proven experience in cellular biology (primary human cell culture, FACS, imaging), molecular biology (RT-qPCR) and biochemistry (western blots, cytokine quantification).
The applicant must be curious, rigorous, dynamic, with a strong sense of organization and team work while being able to work independently, including for the redaction of reports and scientific publications.
English (written/spoken) required; French will be a plus.
The applicant must be vaccinated against Hepaptis B.
In line with CEA commitments for the integration of people with handicaps, this position is open to all.
Position location
Site
Grenoble
Job location
France, Auvergne-Rhône-Alpes, Isère (38)
Location
GRENOBLE
Candidate criteria
Languages
English (Fluent)
Requester
Position start date
01/07/2025