Informations générales
Entité de rattachement
Le CEA est un acteur majeur de la recherche, au service des citoyens, de l'économie et de l'Etat.
Il apporte des solutions concrètes à leurs besoins dans quatre domaines principaux : transition énergétique, transition numérique, technologies pour la médecine du futur, défense et sécurité sur un socle de recherche fondamentale. Le CEA s'engage depuis plus de 75 ans au service de la souveraineté scientifique, technologique et industrielle de la France et de l'Europe pour un présent et un avenir mieux maîtrisés et plus sûrs.
Implanté au cœur des territoires équipés de très grandes infrastructures de recherche, le CEA dispose d'un large éventail de partenaires académiques et industriels en France, en Europe et à l'international.
Les 20 000 collaboratrices et collaborateurs du CEA partagent trois valeurs fondamentales :
• La conscience des responsabilités
• La coopération
• La curiosité
Référence
2024-32781
Description de l'unité
Laboratory: BIOMICS LAB, IRIG, CEA Grenoble (UGA/Inserm/CEA), 17 avenue des Martyrs, 38 054 Grenoble, France. Head of lab: Xavier Gidrol.
We conduct complementary scientific and technological work and coordinate our research to implement our global scientific project aiming at the identification of biomarkers and therapeutic targets, the study of their function, their use for diagnosis and for the development of new therapeutic solutions in the form of drug candidates or biotherapies derived from cell and tissue engineering, as well as tools for bioinformatics analysis of experimental data, mainly in metabolic diseases and cancer.
Description du poste
Domaine
Santé
Contrat
Post-doctorat
Intitulé de l'offre
Post-doctoral fellow in cell biology / biotechnology field H/F
Sujet de stage
Understanding the molecular mechanisms inducing type 1 diabetes using a pancreatic islet model on-chip.
Durée du contrat (en mois)
24
Description de l'offre
Project context: Diabetes is a pandemic that affected 463 million people worldwide in 2019, or 1 in 11 adults. Diabetes, type 1 or 2, causes an abnormal and prolonged increase in blood sugar, mainly caused by deficiency or non-use of insulin. In the long term, diabetes can cause many serious complications.
In our lab, we develop and characterize human organ substitutes, organoids and organoids-on-chip. More specifically, our aim is to develop a vascularized islet-model to understand the molecular mechanisms inducing type 1 diabetes, enabling the screening of new therapeutic targets, drug screening and drug development including immunological approaches.
Project description: This project benefits from a-serpentine-chip which we have already optimized and developed in collaboration with the CEA-Leti. The project involves the development of a pre-vascularized islet model, the development of permissive vascular microenvironment on-chip, the analysis of the vascular network development, and immunological approaches.
Profil du candidat
Candidate profile:
· Highly motivated,
· Background in cell biology, especially vascularization,
· Background in image analysis and quantification (Imaris for eg)
· Background in bioinformatics and transcriptomics analysis would be a plus,
· Strong analytical and organizational skills,
· Ability to work independently and as part of a team,
· Good ability to interact with people.
Localisation du poste
Site
Grenoble
Localisation du poste
France, Auvergne-Rhône-Alpes, Isère (38)
Ville
Grenoble
Demandeur
Disponibilité du poste
01/01/2025