Patient Derived Organoids (PDO) are 3D cell cultures that self-organize to replicate the structure and function of the organs from which they originate, and are derived from patient biopsies. They are highly promising in-vitro models for personalized medicine, drug development and biomedical research. For example, several clinical studies are underway in France and Europe to use these PDOs to guide cancer therapy by observing the response of patient cells to different protocols.

CEA teams are using them for research purposes, and are actively working on the culture and monitoring technologies needed to deploy them in the heathcare system. Microscopy is the preferred method for observing the evolution of PDOs, and monitoring must be performed on a population in order to obtain statistically significant results.

It is in this context that an internship is proposed to develop a tool for rapidly classifying a collection of organoids based on their morphology.

The student will use a differential phase contrast microscope specifically developed in the laboratory to facilitate the observation of thick samples.

He/She will be in charge of acquiring an image database and will be supervised by biologists for the annotation of morphologies of interest.

He/She will use this data to train an artificial intelligence algorithm for classifying morphologies.

His/Her aim will be to systematically optimize the image acquisitions conditions and the classification algorithm to obtain a validated tool that will be made available to the biology team.

This internship is suited to a student preparing a Master 2 degree in image processing, electrical engineering, or equivalent, with a solid knowledge of optoelectronic systems.

Practical experience in AI algorithms for image analysis and microscopy is recommended.

Finally, an interest in biology-health applications is expected.

Join us and develop your skills while acquiring new ones!

Still hesitating? We offer:
- The opportunity to work within a world-renowned organization in the field of scientific research,
- A unique environment dedicated to ambitious projects that address today’s major societal challenges,
- Cutting-edge experience with high potential for industrial development,
- Exceptional experimental resources and high-quality supervision,
- Genuine career opportunities following your internship,
- A position in the heart of the Grenoble metropolitan area, easily accessible through eco-friendly transportation supported by the CEA,
- 85% coverage of public transportation costs,
- A recognized work-life balance,
- An on-site company restaurant,
- A diversity and inclusion policy.

In line with CEA’s commitments to the integration of people with disabilities, this position is open to everyone. The CEA offers accommodations and/or organizational arrangements to support the inclusion of disabled workers.