General information
Organisation
The French Alternative Energies and Atomic Energy Commission (CEA) is a key player in research, development and innovation in four main areas :
• defence and security,
• nuclear energy (fission and fusion),
• technological research for industry,
• fundamental research in the physical sciences and life sciences.
Drawing on its widely acknowledged expertise, and thanks to its 16000 technicians, engineers, researchers and staff, the CEA actively participates in collaborative projects with a large number of academic and industrial partners.
The CEA is established in ten centers spread throughout France
Reference
2024-33898
Position description
Category
Biology, biophysics and biochemistry
Contract
Internship
Job title
Internship - Microencapsculation of pancreatic cells
Subject
Microencapsulation of pancreatic cells for innovative cell therapy against type 1 diabetes
Join the CEA and contribute to an innovative project in the treatment of type 1 diabetes, an autoimmune disease that affects 10% of diabetics worldwide. At the Microfluidic Systems and Biotechnology Laboratory (LSMB), we have been developing innovative solutions for over 10 years, including the microencapsulation of pancreatic cells (islets of Langerhans) in biopolymers to protect them from the immune system without the need of immunosuppression treatment.
Contract duration (months)
6 months
Job description
Your mission will be to participate in an ambitious project in partnership with the University of Grenoble Alpes.
You will work at CEA from an existing experimental device and study the impact of different biopolymers on the production of microcapsules. You will optimize the encapsulation of pancreatic cells which will then be energetically characterized at UGA with the FRET technology developed which will allow real-time monitoring of cellular activity (ATP/ADP and ATP/AMP ratios), to validate the compatibility and efficiency of the encapsulation process.
Main missions
- Optimize the production of spherical microcapsules from biopolymers via a centrifugation system developed at CEA.
- Characterize and analyze the encapsulation of living cells using classic biology methods (morphology, viability).
- Follow the energetic characterization at UGA with FRET technology
- Work in a multidisciplinary environment combining biotechnology, microfluidics and bioengineering.
Applicant Profile
Master 2 student with skills in biotechnology, physics or bioengineering.
Experience in cell manipulation (culture, viability) and notions of biomaterials are a plus.
Good interpersonal skills and ability to work in a multidisciplinary team.
Position location
Site
Grenoble
Job location
France, Auvergne-Rhône-Alpes, Isère (38)
Location
Grenoble
Candidate criteria
Languages
English (Intermediate)
Prepared diploma
Bac+5 - Master 2
Recommended training
Biotechnology, Physics
PhD opportunity
Non
Requester
Position start date
03/02/2025
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