Chronic and serious cases of diabetes type 1 are currently treated by islet grafts. These transplants have a miraculous effect on the quality of life of patients. However, the efficacy and survival rate of the implant diminishes over the years.

At CEA-Leti we are starting a long-term ambitious project in collaboration with the Grenoble Alpes University Hospital to develop biological twin models following patients’ transplants. We aim to provide clinicians with insights into the patient’s immune response allowing them to better make clinical decisions.

We are currently seeking a motivated and talented researcher to join our team.

Our objectives are to design, prototype and validate a microfluidic platform with monitoring and multisensing approaches enabling the study of interactions between transplanted islets and immune cells isolated from the islet recipient, as a predictive tool for clinicians of islet transplant rejection and immune relapse and/or loss of efficacy of immunosuppressive treatment.

You will contribute to the development of a modular microfluidic platform dedicated to organ-on-chip applications. The position has a strong accent on microfluidic experimentation in order to ensure robustness and reliability of the system. In close collaboration with experts in biology, manufacturing and sensor technologies, you will be responsible for the microfluidic aspects of the biological experiments. The position requires you to be pragmatic and hands-on in your role as a facilitator.

Your activities will include:

• microfluidic experimentation with or without biological components
• characterization of microfluidic devices
• setting up test environments
• using and improving software for control and acquisition
• analysis and interpretation of results

Engineer (MSc) and/or doctor (PhD), you have strong expertise in microfluidic development.

Knowledge in microfluidic development is required and experience in organ-on-chip would be a plus.

Attracted by a multi-disciplinary environment and technological innovation, you are committed to achieving results in your projects.

Motivated by experimental work (bench work), you know how to work as part of a team with a wide variety of people.

Rigor, dynamism and organizational skills will be particularly appreciated. Fluency in English is a must.

In line with CEA's commitment to the integration of disabled people, this position is open to all. The CEA offers accommodation and/or organizational possibilities for the inclusion of disabled workers.